Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Frs2tm1Fwan
Name:	fibroblast growth factor receptor substrate 2; targeted mutation 1, Fen Wang
MGI ID:	MGI:3768912
Synonyms:	Frs2alphaflox, Frs2alphafloxneo
Gene:	Frs2  Location: Chr10:116905332-116984439 bp, - strand  Genetic Position: Chr10, 65.09 cM
Alliance:	Frs2tm1Fwan page

Germline Transmission:	Earliest citation of germline transmission: J:128712
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exon 5 was flanked by loxP sites with one loxP site placed immediately upstream and the other placed 600 bp downstream. A FRT-flanked neo selection cassette was placed between the exon and the downstream loxP site. Mice were crossed with FLP expressing knock-in mice to remove the neo cassette. Insertion of the loxP sites were presumed not to effect gene expression because homozygote mice were born at Mendelian frequencies. (J:128712)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

List all tumor models in MMHCdb carrying Frs2tm1Fwan

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Frs2 Mutation:	64 strains or lines available

Original:	J:128712 Lin Y, et al., Generation of an Frs2alpha conditional null allele. Genesis. 2007 Sep;45(9):554-9
All:	26 reference(s)