Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tgfb3tm2(Tgfb1)Vk
Name:	transforming growth factor, beta 3; targeted mutation 2, Vesa Kaartinen
MGI ID:	MGI:3768675
Synonyms:	Tgfb1-KI
Gene:	Tgfb3  Location: Chr12:86103519-86125815 bp, - strand  Genetic Position: Chr12, 40.09 cM
Alliance:	Tgfb3tm2(Tgfb1)Vk page

Germline Transmission:	Earliest citation of germline transmission: J:128938
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inserted expressed sequence, Null/knockout) Mutation:    Insertion   Mutation details: A vector containing Tgfb1 cDNA followed by a pgk polyA sequence and a loxP flanked neomycin resistance cassette was inserted into the ATG start site of the targeted gene. Quantitative RT-PCR of RNA isolated from the tips of the palatal shelves demonstrates high Tgfb1 expression but no Tgfb3 expression in homozygotes. (J:128938)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tgfb3 Mutation:	34 strains or lines available

Original:	J:128938 Yang LT, et al., Tgfb1 expressed in the Tgfb3 locus partially rescues the cleft palate phenotype of Tgfb3 null mutants. Dev Biol. 2007 Dec 1;312(1):384-95
All:	1 reference(s)