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Chst11Gt(PT-1)1Wran
Gene trapped Allele Detail
Summary
Symbol: Chst11Gt(PT-1)1Wran
Name: carbohydrate sulfotransferase 11; gene trap 1, Jeffrey L Wrana
MGI ID: MGI:3768254
Synonyms: C4st1gt
Gene: Chst11  Location: Chr10:82821332-83031734 bp, + strand  Genetic Position: Chr10, 40.66 cM, cytoband C1
Alliance: Chst11Gt(PT-1)1Wran page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:128547
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector
 
Mutation detailsThe gene trap vector PT-1 was inserted into intron 1 resulting in a fusion transcript encoding exon1 and lacZ. LacZ expression was monitored by beta-galactosidase assay. Expression analysis confirmed the lack of expression of exons 2 and 3 and reduced protein function was monitored by increasing En2 expression. This allele is likely to be a null allele. (J:128547)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 17 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chst11 Mutation:  18 strains or lines available
References
Original:  J:128547 Kluppel M, et al., Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis. Development. 2005 Sep;132(17):3989-4003
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory