Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rapgef4tm1.1Sse
Name:	Rap guanine nucleotide exchange factor (GEF) 4; targeted mutation 1.1, Susumu Seino
MGI ID:	MGI:3767602
Synonyms:	Epac2ko
Gene:	Rapgef4  Location: Chr2:71811584-72087818 bp, + strand  Genetic Position: Chr2, 42.9 cM, cytoband C3
Alliance:	Rapgef4tm1.1Sse page

Germline Transmission:	Earliest citation of germline transmission: J:128493
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted into exon 1 and a floxed neo cassette was inserted downstream of exon 1. Cre-mediated recombination was used to delete a portion of exon 1. The absence of protein product in pancreatic islet cells was confirmed by RT-PCR analysis. (J:128493)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rapgef4 Mutation:	64 strains or lines available

Original:	J:128493 Shibasaki T, et al., Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19333-8
All:	14 reference(s)