Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Fbxw7tm1Kei
Name:	F-box and WD-40 domain protein 7; targeted mutation 1, Keiichi Nakayama
MGI ID:	MGI:3767577
Synonyms:	Fbxw7F
Gene:	Fbxw7  Location: Chr3:84722575-84886505 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3
Alliance:	Fbxw7tm1Kei page

Germline Transmission:	Earliest citation of germline transmission: J:128523
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed neo cassette was inserted upstream of exon 5 with an additional loxP site inserted downstream of exon 5. Cre-mediated recombination using a transiently transfected pMC-Cre vector was used to remove the neo cassette. (J:128523)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

List all tumor models in MMHCdb carrying Fbxw7tm1Kei

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fbxw7 Mutation:	82 strains or lines available

Original:	J:128523 Onoyama I, et al., Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med. 2007 Nov 26;204(12):2875-88
All:	16 reference(s)