Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pitx2tm1Hmd
Name:	paired-like homeodomain transcription factor 2; targeted mutation 1, Hiroshi Hamada
MGI ID:	MGI:3767234
Synonyms:	Pitx2deltaASE
Gene:	Pitx2  Location: Chr3:128993527-129013240 bp, + strand  Genetic Position: Chr3, 57.84 cM
Alliance:	Pitx2tm1Hmd page

Germline Transmission:	Earliest citation of germline transmission: J:128475
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J X (C57BL/6 x C3H)F1

Allele Type:    Targeted (Modified regulatory region) Mutation:    Intragenic deletion   Mutation details: The 0.6 kb intronic enhancer (ASE) region was replaced with a neo cassette that was subsequently removed by cre-mediated recombination following electroporation of a CAG-cre vector. Deletion was confirmed by PCR. (J:128475)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

15 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pitx2 Mutation:	38 strains or lines available

Original:	J:128475 Shiratori H, et al., Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs. Development. 2006 Aug;133(15):3015-25
All:	7 reference(s)