Gt(ROSA)26Sortm3(phiC31*)Sor
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm3(phiC31*)Sor |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Philippe Soriano |
MGI ID: |
MGI:3766932 |
Synonyms: |
R26phiC31o |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm3(phiC31*)Sor page
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Germline Transmission: |
Earliest citation of germline transmission:
J:128069
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Parent Cell Line: |
AK7.1 (ES Cell)
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Strain of Origin: |
129S4/SvJaeSor
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm3(phiC31*)Sor expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Gt(ROSA)26Sor (MGI:104735) |
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Mutation details: A targeting construct with the SA-PhiC31opA-PGKneopA cassette, which contains the mouse codon-optimized site-specific recombinase PhiC31o sequence (with a C-terminal SV40 nuclear localization signal) driven by the phosphoglycerate kinase 1 (PGK) promoter, and bovine growth hormone polyadenylation (bpA) sequence was inserted into the Gt(ROSA)26Sor locus. Flp-mediated recombination removes the neo cassette. PhiC31o-mediated recombination in mice carrying containing a sequence of interest flanked by attB and attP sites results in tissue-specific deletion of the targeted sequence.
(J:128069)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Gt(ROSA)26Sor
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:128069 Raymond CS, et al., High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells. PLoS One. 2007;2(1):e162 |
All: |
20 reference(s) |
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