Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fasntm1.1Sem
Name:	fatty acid synthase; targeted mutation 1.1, Clay F Semenkovich
MGI ID:	MGI:3765071
Synonyms:	FAS-deficient
Gene:	Fasn  Location: Chr11:120696672-120715373 bp, - strand  Genetic Position: Chr11, 84.56 cM
Alliance:	Fasntm1.1Sem page

Germline Transmission:	Earliest citation of germline transmission: J:127793
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Mice carrying the Fasntm1Sem allele were crossed with Cre transgenic mice to remove exons 4-8 of the gene. Germline deletion of the exons was verified by PCR, and gene inactivation was demonstrated by a 50% reduction in enzyme activity in liver lysates from heterozygote. (J:127793)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fasn Mutation:	88 strains or lines available

Original:	J:127793 Chakravarthy MV, et al., 'New' hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab. 2005 May;1(5):309-22
All:	3 reference(s)