Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gdf3Gt(AD0857)Wtsi
Name:	growth differentiation factor 3; gene trap AD0857, Wellcome Trust Sanger Institute
MGI ID:	MGI:3764814
Synonyms:	Gdf3-
Gene:	Gdf3  Location: Chr6:122582362-122587046 bp, - strand  Genetic Position: Chr6, 57.7 cM
Alliance:	Gdf3Gt(AD0857)Wtsi page

Mutant Cell Line:	AD0857
Germline Transmission:	Earliest citation of germline transmission: J:127541
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Sanger Inst. Gene Trap Res.

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector     Vector: pGT0lxr   Mutation details: A genetrap vector consisting of a splice acceptor site and a single loxP site upstream of a frt flanked beta-geo cassette inserted into the only intron of the gene. No gene expression was detected in homozygous embryos or adult spleen tissue by RT-PCR. (J:127541) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select AD0857 CL459123 (MGI Seq Detail) 5' RACE Chr6:122586654-122586836 bp (-) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 29 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gdf3 Mutation:	40 strains or lines available

Original:	J:127541 Andersson O, et al., Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol. 2007 Nov 15;311(2):500-11
All:	2 reference(s)