Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Itgb7tm1Mshi
Name:	integrin beta 7; targeted mutation 1, Motomu Shimaoka
MGI ID:	MGI:3764672
Synonyms:	Itgb7D146A
Gene:	Itgb7  Location: Chr15:102124430-102140379 bp, - strand  Genetic Position: Chr15, 57.39 cM
Alliance:	Itgb7tm1Mshi page

Germline Transmission:	Earliest citation of germline transmission: J:127413
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Constitutively active) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A vector consisting of a cre recombinase and a neomycin resistant gene under the control of the sperm-specific ACE promoter was used for targeting exon 4. In exon 4, the sequence encoding amino acid 146 was changed from an aspartate to an alanine (D146A). This mutation was predicted to keep the integrin in a constitutively adhesive state. The cre-recombinase and the neomycin resistance gene were excised in chimeras during spermatogenesis, leaving behind one loxP site. The mutation was confirmed by genomic sequencing. (J:127413)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb7 Mutation:	72 strains or lines available

Original:	J:127413 Park EJ, et al., Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. J Clin Invest. 2007 Sep;117(9):2526-38
All:	2 reference(s)