Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mir155tm1.1Rsky
Name:	microRNA 155; targeted mutation 1.1, Klaus Rajewsky
MGI ID:	MGI:3763386
Synonyms:	bic/miR-155-, miR-155KO
Gene:	Mir155  Location: Chr16:84511028-84511092 bp, + strand  Genetic Position: Chr16, 46.92 cM
Alliance:	Mir155tm1.1Rsky page

Germline Transmission:	Earliest citation of germline transmission: J:121084
Parent Cell Line:	F1H4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NTac)F1

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A modified bacterial artificial chromosome (BAC) targeting vector was used to replace a 0.97 kb portion of exon 2 of the bic/mir-155 gene with an in-frame b-galactosidase (lacZ) reporter gene (with polyA sequence and followed by a loxP-flanked neomycin resistance cassette). The mice were bred with a cre-deleter strain (congenic C57BL/6 background) to remove the loxP-flanked selection cassette. The resulting bic/mir-155 mutant mice (with lacZ followed by a single remaining loxP site). In heterozygotes, approximately 60% of germinal center (GC) B cells express the lacZ reporter whereas the vast majority of the non-GC B cells do not. (J:121084)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mir155 Mutation:	11 strains or lines available

Original:	J:121084 Thai TH, et al., Regulation of the germinal center response by microRNA-155. Science. 2007 Apr 27;316(5824):604-8
All:	117 reference(s)