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Git2Gt(XG510)Byg
Gene trapped Allele Detail
Summary
Symbol: Git2Gt(XG510)Byg
Name: GIT ArfGAP 2; gene trap XG510, BayGenomics
MGI ID: MGI:3762635
Synonyms: GIT2-
Gene: Git2  Location: Chr5:114865469-114912647 bp, - strand  Genetic Position: Chr5, 55.99 cM
Alliance: Git2Gt(XG510)Byg page
Mutation
origin
Mutant Cell Line:  XG510
Germline Transmission:  Earliest citation of germline transmission: J:126878
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
 
Mutation detailsA gene trap vetor containing a beta-geo cassette was inserted into intron 2. Insertion was confirmed by PCR genotyping and expression of the lacZ gene was confirmed by beta-galactosidase staining. Two transcripts were detected by RT-PCR: one the expected fusion of exon 1 and 2 to the gene trap vector sequence and the other an alternative transcript lacking exon 2. (J:126878)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Git2 Mutation:  78 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:126878 Schmalzigaug R, et al., Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. J Histochem Cytochem. 2007 Oct;55(10):1039-48
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory