Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(KLK3-cre)D4Trp
Name:	transgene insertion D4, Jan Trapman
MGI ID:	MGI:3761848
Synonyms:	PSA-cre, PSA-creD4
Transgene:	Tg(KLK3-cre)D4Trp  Location: unknown
Alliance:	Tg(KLK3-cre)D4Trp page

Strain of Origin:

FVB

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(KLK3-cre)D4Trp expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note human KLK3 (354) Klk1  (MGI:102850) Klk1b1  (MGI:892019) Klk1b3  (MGI:97322) Klk1b4  (MGI:97320) Klk1b5  (MGI:892020) Klk1b8  (MGI:892018) Klk1b9  (MGI:95293) Klk1b11  (MGI:892023) Klk1b16  (MGI:891982) Klk1b21  (MGI:892022) Klk1b22  (MGI:95291) Klk1b24  (MGI:892021) Klk1b26  (MGI:891981) Klk1b27  (MGI:891980)   Mutation details: The construct uses the human prostate-specific antigen promoter (referred to as PSA; proper designation KLK3) to drive transcription of the cre recombinase cDNA. The transgene was injected into fertilized FVB oocytes. Prostate-specific expression was verified by crossing to Tg(ACTB-cat,-lacZ)34Pva transgenic mice. Founder line D4 showed high, prostate-specific cre activity. (J:99524)

Activity:	Tissue activity of this recombinase allele
Driver:	KLK3 (human) Summary of all recombinase alleles driven by KLK3. Alliance human KLK3 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Tg(KLK3-cre)D4Trp

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:99524 Ma X, et al., Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. Cancer Res. 2005 Jul 1;65(13):5730-9
All:	7 reference(s)