Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il22tm1Flv
Name:	interleukin 22; targeted mutation 1, Richard A Flavell
MGI ID:	MGI:3761615
Synonyms:	Il22-
Gene:	Il22  Location: Chr10:118040847-118045952 bp, + strand  Genetic Position: Chr10, 66.67 cM
Alliance:	Il22tm1Flv page

Germline Transmission:	Earliest citation of germline transmission: J:126103
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	(129/Sv x C57BL/6)F1

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 through 4 were replaced by the pZEN6 cassette containing a reporter lacZ gene with a transmembrane domain and a floxed neo cassette. (J:126103)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il22 Mutation:	27 strains or lines available

Original:	J:126103 Zenewicz LA, et al., Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity. 2007 Oct;27(4):647-59
All:	20 reference(s)