Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Diaph1tm1Sna
Name:	diaphanous related formin 1; targeted mutation 1, Shuh Narumiya
MGI ID:	MGI:3761498
Gene:	Diaph1  Location: Chr18:37976654-38068529 bp, - strand  Genetic Position: Chr18, 19.71 cM
Alliance:	Diaph1tm1Sna page

Germline Transmission:	Earliest citation of germline transmission: J:126090
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 1 and a neo cassette flanked by frt sites and containing a 3' loxP site was inserted downstream of exon 1. Insertion was confirmed by PCR and Southern blot analysis. (J:126090)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Diaph1 Mutation:	116 strains or lines available

Original:	J:126090 Sakata D, et al., Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1. J Exp Med. 2007 Sep 3;204(9):2031-8
All:	3 reference(s)