Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Wasltm2Sbs Name: WASP like actin nucleation promoting factor; targeted mutation 2, Scott B Snapper MGI ID: MGI:3760279 Synonyms: N-WASpfl, N-WASP L2L Gene: Wasl  Location: Chr6:24613804-24665008 bp, - strand  Genetic Position: Chr6, 11.28 cM, cytoband A3 Alliance: Wasltm2Sbs page

Hypoplasia and loss of glomeruli and proximal tubules in Wasltm2Sbs/Wasltm2Sbs Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ kidneys Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:125309
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed neo cassette was inserted downstrem of exon 2 and an additional loxP site upstream of exon 2. The neo cassette was deleted by transient Cre recombinase expression. Insertion was confirmed by Southern blot analysis. (J:125309)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wasl Mutation:	39 strains or lines available

Original:	J:125309 Cotta-de-Almeida V, et al., Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15424-9
All:	15 reference(s)