Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Zic1tr,-lacZ)1Jaru
Name:	transgene insertion 1, Jun Aruga
MGI ID:	MGI:3759865
Synonyms:	TR9K
Transgene:	Tg(Zic1tr,-lacZ)1Jaru  Location: unknown
Alliance:	Tg(Zic1tr,-lacZ)1Jaru page

Strain of Origin:

(C57BL/6 x DBA/2)F1

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Zic1tr,-lacZ)1Jaru expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Zic1 (MGI:106683)   Mutation details: The transgene consists of a 9-kb mouse genomic DNA fragment encompassing the coding region of the zinc finger protein of the cerebellum (Zic1) gene and 2.9 kb of 5' flanking DNA containing the proximal promoter and dorsal spinal cord enhancer, with a termination linker inserted 475 bp downstream of the initiation codon to terminate translation prematurely within the N -terminal region of the protein and with an IRES-lacZ cassette inserted into the gene's 3'-untranslated region. (J:76132)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:76132 Aruga J, et al., Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation. Dev Biol. 2002 Apr 15;244(2):329-41
All:	1 reference(s)