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Gene Expression Data
Assay Details
Assay
Reference: J:124438 Poirier K, et al., Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A). Hum Mutat. 2007 Nov;28(11):1055-64
Assay type: RNA in situ
MGI Accession ID: MGI:3759489
Gene symbol: Tuba1a
Gene name: tubulin, alpha 1A
Probe: Tuba1a cDNA
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: brainstem Strong 3C
TS24: cerebellum Strong 3C
TS24: diencephalon Strong 3C
TS24: dorsal root ganglion Strong 3C
TS24: midbrain Strong 3C
TS24: spinal cord Strong 3C
TS24: telencephalon Strong 3C
TS24: cerebral cortex intermediate zone Present 3E In the developing cerebral cortex, expression predominates in a thin layer within the intermediate and cortical plate.
TS24: cortical plate Present 3E In the developing cerebral cortex, expression predominates in a thin layer within the intermediate and cortical plate.
TS24: cerebral cortex ventricular layer Weak 3E Faint signals are seen within the ventricular zone and the intermediate zone.

Specimen P10: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: brain Present 3D Expression is observed in all brain regions.
TS28: cerebral cortex Present 3G , 3D This is one of the structures with the most intense expression levels.
TS28: brainstem Present 3D This is one of the structures with the most intense expression levels.
TS28: cerebellum Present 3D This is one of the structures with the most intense expression levels.
TS28: hippocampus Present 3D This is one of the structures with the most intense expression levels.
TS28: rostral migratory stream Present 3D Some of the most intense expression is found in the rostral migratory stream.

Specimen Older postnatal: postnatal (more )
Structure Level Pattern Image Note
TS28: brain Present At postnatal ages later than P20 and adult stages, expression levels significantly decrease.
TS28: hippocampus Weak A low level of expression persists in the hippocampus.
TS28: rostral migratory stream Weak A low level of expression persists in the rostral migratory stream.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory