Tg(Myh6/tetO-Myl4)12Rbns
Transgene Detail
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| Symbol: |
Tg(Myh6/tetO-Myl4)12Rbns |
| Name: |
transgene insertion 12, Jeffrey Robbins |
| MGI ID: |
MGI:3757952 |
| Synonyms: |
MHCminTetO-ELC1a |
| Transgene: |
Tg(Myh6/tetO-Myl4)12Rbns Location: unknown
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| Alliance: |
Tg(Myh6/tetO-Myl4)12Rbns page
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| Strain of Origin: |
Not Applicable
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| Transgene Type: |
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Transgenic (Inducible, Inserted expressed sequence) |
| Inducer: |
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doxycycline/tetracycline |
| Mutation: |
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Insertion
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Mutation details: This transgene contains the atrium specific form of Myl4 under transcriptional control of a minimally active mouse alpha myosin heavy chain (Myh6) promoter fused to seven copies of the tetracycline-responsive promoter element (tetO). To make the Myh6 promoter minimally active, three GATA sites and two thyroid-like response elements are ablated. When bred with transgenic mice expressing a tetracycline transactivator or reverse transactivator protein, cardiac-specific expression of Myl4 can be controlled by withdrawal or administration of a tetracycline analog.
(J:125131)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:125131 Sanbe A, et al., Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter. Circ Res. 2003 Apr 4;92(6):609-16 |
| All: |
1 reference(s) |
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Analysis Tools
