Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ntng2tm1Ito
Name:	netrin G2; targeted mutation 1, Shigeyoshi Itohara
MGI ID:	MGI:3757587
Synonyms:	Ntng2 KO
Gene:	Ntng2  Location: Chr2:29084738-29138111 bp, - strand  Genetic Position: Chr2, 19.57 cM, cytoband A3
Alliance:	Ntng2tm1Ito page

Germline Transmission:	Earliest citation of germline transmission: J:124961
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP-flanked neomycin resistance cassette replaced part of the upstream UTR and coding region of this gene. Mice were crossed with Cre recombinase transgenic mice to remove the neo cassette. Northern blot and immunohistochemical analysis on brains of homozygous mice confirmed lack of expression of this gene with no compensatory increases in expression of the related Ntng1 gene. (J:124961)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntng2 Mutation:	34 strains or lines available

Original:	J:124961 Nishimura-Akiyoshi S, et al., Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14801-6
All:	4 reference(s)