Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gpr39tm1Lex
Name:	G protein-coupled receptor 39; targeted mutation 1, Lexicon Genetics
MGI ID:	MGI:3723512
Gene:	Gpr39  Location: Chr1:125604732-125801599 bp, + strand  Genetic Position: Chr1, 54.7 cM, cytoband E3
Alliance:	Gpr39tm1Lex page

Germline Transmission:	Earliest citation of germline transmission: J:124913
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: An IRESLacZ reporter and a neo selection cassette replaced a 1051 bp genomic fragment including all but the first 92 bp of exon 1. Quantitative RT-PCR indicated that heterozygote mice expressed about half the level of mRNA as wild-type mice, with no mRNA being detected in homozygote mice. LacZ expression was detected in the stomach, intestines, pancreas and brain of homozygote mice. (J:124913)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gpr39 Mutation:	28 strains or lines available

Original:	J:124913 Moechars D, et al., Altered gastrointestinal and metabolic function in the GPR39-obestatin receptor-knockout mouse. Gastroenterology. 2006 Oct;131(4):1131-41
All:	4 reference(s)