Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gabrg2tm1Wul
Name:	gamma-aminobutyric acid type A receptor, subunit gamma 2; targeted mutation 1, Peter Wulff
MGI ID:	MGI:3721943
Synonyms:	gamma2I77lox
Gene:	Gabrg2  Location: Chr11:41801030-41891684 bp, - strand  Genetic Position: Chr11, 24.8 cM
Alliance:	Gabrg2tm1Wul page

Germline Transmission:	Earliest citation of germline transmission: J:124171
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Exon 4 was replaced with an exon containing a phenylalanine to isoleucine mutation at position 77 (F77I). This point mutation confers drug insensitivity to zolpidem. A loxP site was inserted in the upstream intron and a frt-flanked neomycin cassette followed by another loxP site was inserted in the downstream intron. Chimeric mice were mated with a Flp deleter strain to remove the neomycin cassette. Genomic sequencing of homozygous mice confirmed the presence of the F to I mutation. (J:124171)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabrg2 Mutation:	41 strains or lines available

Original:	J:124171 Wulff P, et al., From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors. Nat Neurosci. 2007 Jul;10(7):923-9
All:	25 reference(s)