Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Siglec1tm1(HBEGF)Mtka
Name:	sialic acid binding Ig-like lectin 1, sialoadhesin; targeted mutation 1, Masato Tanaka
MGI ID:	MGI:3720841
Synonyms:	CD169DTR, CD169-DTR
Gene:	Siglec1  Location: Chr2:130911140-130928685 bp, - strand  Genetic Position: Chr2, 63.26 cM, cytoband F-H1
Alliance:	Siglec1tm1(HBEGF)Mtka page

Germline Transmission:	Earliest citation of germline transmission: J:123958
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inserted expressed sequence, Null/knockout) Mutation:    Insertion   Siglec1tm1(HBEGF)Mtka expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human HBEGF (1839) Hbegf  (MGI:96070)   Mutation details: A 28-bp fragment including the endogenous ATG in exon 1 was replaced with human heparin-binding EGF-like growth factor and a floxed neo cassette. (J:123958)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Siglec1 Mutation:	82 strains or lines available

Original:	J:123958 Miyake Y, et al., Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J Clin Invest. 2007 Aug;117(8):2268-78
All:	61 reference(s)