Tg(APOE-DGAT2)24Far
Transgene Detail
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| Symbol: |
Tg(APOE-DGAT2)24Far |
| Name: |
transgene insertion 24, Bob Farese |
| MGI ID: |
MGI:3720356 |
| Synonyms: |
Liv-DGAT2-low, LivLe6-DGAT2 (low) |
| Transgene: |
Tg(APOE-DGAT2)24Far Location: unknown
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| Alliance: |
Tg(APOE-DGAT2)24Far page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(APOE-DGAT2)24Far expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
DGAT2 (84649) |
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Mutation details: The LivLE6-DGAT2 transgene was designed with promoter and enhancer sequences of the human apolipoprotein E gene placed upstream of a 1.2 kb human acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) cDNA sequence. This transgene was microinjected into C57BL/6NHsd fertilized eggs, and the resulting transgenic offspring were bred to C57BL/6NHsd. Mice from founder line 24 (referred to as Liv-DGAT2-low) have an approximately 2-fold increase in total hepatic DGAT2 mRNA/protein expression, with no reported overexpression in kidney, brain, or skeletal muscle.
(J:124005)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:124005 Monetti M, et al., Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 2007 Jul;6(1):69-78 |
| All: |
2 reference(s) |
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Analysis Tools
