Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tgfb1tm2Flv
Name:	transforming growth factor, beta 1; targeted mutation 2, Richard A Flavell
MGI ID:	MGI:3719583
Synonyms:	TGF-b1-GFP, Tgfb1n
Gene:	Tgfb1  Location: Chr7:25386427-25404502 bp, + strand  Genetic Position: Chr7, 13.98 cM
Alliance:	Tgfb1tm2Flv page

Germline Transmission:	Earliest citation of germline transmission: J:123547
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A green-fluorescent protein was inserted into the first exon of the gene to generate a null allele. A floxed neo cassette inserted downstream of the modified exon 1 was removed by cre-mediated recombination. (J:123547)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfb1 Mutation:	34 strains or lines available

Original:	J:123547 Li MO, et al., T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity. 2007 May;26(5):579-91
All:	9 reference(s)