Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aqp9tm1Nlsn
Name:	aquaporin 9; targeted mutation 1, Soren Nielsen
MGI ID:	MGI:3719452
Synonyms:	Aqp9-
Gene:	Aqp9  Location: Chr9:71017941-71075170 bp, - strand  Genetic Position: Chr9, 39.85 cM, cytoband D
Alliance:	Aqp9tm1Nlsn page

Germline Transmission:	Earliest citation of germline transmission: J:123742
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced 55 nucleotides in exon 2. The insertion was predicted to result in correct translation of the initial 47 amino acids followed by 100 random amino acids and a stop codon. RT-PCR confirmed correct integration of the mutation. An aberrantly spliced transcript was detected, where exon 1 was fused to exon 3, however, the production of protein from this transcript is unlikely. (J:123742)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aqp9 Mutation:	29 strains or lines available

Original:	J:123742 Rojek AM, et al., Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3609-14
All:	14 reference(s)