Gene Expression Data
Assay Details
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Assay
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Reference:
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J:77732
Rokosh DG, et al., Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9474-9
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Assay type:
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In situ reporter (knock in)
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MGI Accession ID:
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MGI:3716909
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Gene symbol:
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Adra1a
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Gene name:
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adrenergic receptor, alpha 1a
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Reporter:
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lacZ
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Direct Detection
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Results
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Specimen
1D Het:
embryonic day 12.5; Adra1atm1Pcs/Adra1a +
(more  )
Specimen
1D Het:
(close  )
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Genetic Background:
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involves: 129X1/SvJ * FVB/N
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Mutant Allele(s):
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Adra1atm1Pcs/Adra1a+
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Age:
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embryonic day 12.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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Specimen
1D KO:
(close )
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Genetic Background:
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involves: 129X1/SvJ * FVB/N
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Mutant Allele(s):
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Adra1atm1Pcs/Adra1atm1Pcs
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Age:
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embryonic day 12.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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Specimen
Not shown:
(close )
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Genetic Background:
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involves: 129X1/SvJ * FVB/N
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Mutant Allele(s):
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Adra1atm1Pcs/Adra1atm1Pcs
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Age:
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postnatal adult
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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Specimen
2A:
(close )
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Genetic Background:
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involves: 129X1/SvJ * FVB/N
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Mutant Allele(s):
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Adra1atm1Pcs/Adra1atm1Pcs
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Age:
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postnatal
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: aorta |
Present |
Regionally restricted |
2A
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Expression is absent at the level shown (thoracic aorta) but is present in the abdominal aorta just above the level of the celiac artery (shown in 2B) and around branch artery origins (2C).
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| TS28: carotid artery |
Absent |
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2A
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| TS28: pulmonary artery |
Absent |
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2A
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Expression is absent in the proximal pulmonary artery.
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Specimen
2B:
(close )
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Genetic Background:
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involves: 129X1/SvJ * FVB/N
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Mutant Allele(s):
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Adra1atm1Pcs/Adra1atm1Pcs
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Age:
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postnatal
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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Specimen
2C:
(close )
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Genetic Background:
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involves: 129X1/SvJ * FVB/N
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Mutant Allele(s):
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Adra1atm1Pcs/Adra1atm1Pcs
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Age:
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postnatal
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: aorta |
Present |
Regionally restricted |
2C
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Expression is in the abdominal aorta just above the level of the celiac artery (2B) and around branch artery origins (2C).
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| TS28: celiac artery |
Present |
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2C
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Specimen
2D:
(close )
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Genetic Background:
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involves: 129X1/SvJ * FVB/N
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Mutant Allele(s):
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Adra1atm1Pcs/Adra1atm1Pcs
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Age:
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postnatal
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: renal artery |
Present |
Regionally restricted |
2D
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Expression is in the renal artery in a circumferential pattern.
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Specimen
2E:
(close )
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Genetic Background:
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involves: 129X1/SvJ * FVB/N
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Mutant Allele(s):
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Adra1atm1Pcs/Adra1atm1Pcs
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Age:
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postnatal
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: skin |
Strong |
Regionally restricted |
2E
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Expression is in dermal arterioles near hair follicles.
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Specimen
2F:
(close )
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Genetic Background:
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involves: 129X1/SvJ * FVB/N
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Mutant Allele(s):
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Adra1atm1Pcs/Adra1atm1Pcs
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Age:
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postnatal
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: skin |
Strong |
Regionally restricted |
2F
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Expression is in dermal arterioles near hair follicles.
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Analysis Tools