Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Liqun Luo
MGI ID:	MGI:3716464
Synonyms:	Gt(ROSA26)ACTB-tdTomato-EGFP, mTmG, mT/mG, mTomato/mEGFP, R26-mR/mG, R26TG, R26-X, Rosa26flox-mTRed-Stop-flox-mGFP, ROSA26-mGFP, Rosa26mTmG, ROSA26-mTmG, Rosa26mTmGflox, Rosa26RmTmG, ROSAmT-mE, RosamTmG, ROSA-mT/mG, ROSA-R/G, TomatoGFP+
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo page

Germline Transmission:	Earliest citation of germline transmission: J:124702
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, Reporter) Mutation:    Insertion   Mutation details: The targeting vector was designed with a CMV enhancer/chicken beta-actin core promoter (pCA) driving expression of a loxP-flanked, N-terminal membrane-tagged, optimized DsRed fluorescent protein variant (called tandem-dimer-Tomato or tdTomato) sequence followed by a polyadenylation signal. Immediately distal to the second loxP site is an N-terminal membrane-tagged, enhanced green fluorescent protein (EGFP) sequence itself followed by a polyadenylation signal. An frt-flanked neo cassette was also located distal to the expression vector. Red fluorescence is detected in all tissues tested. When mice are bred to Cre expressing mice, the floxed region is excised in Cre-expressing tissue and this allows expression of the EGFP cassette. (J:123053, J:124702)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

434 assay results 22 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 10 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:124702 Muzumdar MD, et al., A global double-fluorescent Cre reporter mouse. Genesis. 2007 Sep;45(9):593-605
All:	1871 reference(s)