Tg(Thy1-CFP/COX8A)S2Lich
Transgene Detail
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| Symbol: |
Tg(Thy1-CFP/COX8A)S2Lich |
| Name: |
transgene insertion S2, Jeff W Lichtman |
| MGI ID: |
MGI:3715464 |
| Synonyms: |
mitoCFP, MitoMouse, mtCFP, Thy1-CFP-MitoS, Thy1-mitoCFP-S, Thy1-mtCFP |
| Transgene: |
Tg(Thy1-CFP/COX8A)S2Lich Location: unknown
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| Alliance: |
Tg(Thy1-CFP/COX8A)S2Lich page
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| Strain of Origin: |
C57BL/6 and CBA
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| Transgene Type: |
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Transgenic (Reporter) |
| Mutation: |
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Insertion
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Mutation details: A transgenic construct containing the entire open reading frame of the Cyan Fluorescent Protein (CFP) gene fused in-frame with the mitochondrial targeting sequence of the human cytochrome c oxidase subunit 8A (ubiquitous) gene under the direction of regulatory elements derived from the mouse Thy1 gene was injected into fertilized donor mouse eggs. Regulatory elements are composed of a 6.5 kb fragment obtained from the 5' portion of the Thy1 gene, extending from the promoter to the intron following exon 4. Exon 3 and its flanking introns are absent. The deleted sequences are required for expression in non-neural cells but not in neurons. The remainder of the sequence is required for neuronal expression. Founder line S2, corresponding to the published line S, was subsequently established.
(J:122259)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Founder line S2 corresponds to the published line S.
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| Original: |
J:122259 Misgeld T, et al., Imaging axonal transport of mitochondria in vivo. Nat Methods. 2007 Jul;4(7):559-561 |
| All: |
25 reference(s) |
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Analysis Tools
