Summary | Transgene origin | Transgene description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Cyp11a1-cre)16Mchu
Name:	transgene insertion 16, Meng-Chun Hu
MGI ID:	MGI:3712926
Synonyms:	SCC-iCre
Transgene:	Tg(Cyp11a1-cre)16Mchu  Location: unknown
Alliance:	Tg(Cyp11a1-cre)16Mchu page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Cyp11a1-cre)16Mchu expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Cyp11a1   Mutation details: This transgene uses the cytochrome P450, family 11, subfamily a, polypeptide 1 promoter to drive expression of the codon-improved cre recombinase (iCre) in the adrenal cortex and gonads, as well as the diencephalons and midbrain. Two copies of the HS4 insulator sequences derived from chicken beta-globin LCR were inserted into the cassette either upstream or downstream of the construct in reverse direction. Lines 30 and 41 were also made and expressed at a similar high level and in a consistent pattern. (J:121826)

Activity:	Tissue activity of this recombinase allele
Driver:	Cyp11a1 (species not specified) Summary of all recombinase alleles driven by Cyp11a1. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:121826 Wu HS, et al., Human CYP11A1 promoter drives Cre recombinase expression in the brain in addition to adrenals and gonads. Genesis. 2007 Feb;45(2):59-65
All:	6 reference(s)