Tg(CAG-OTC/CAT)4033Prab
Transgene Detail
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| Symbol: |
Tg(CAG-OTC/CAT)4033Prab |
| Name: |
transgene insertion 4033, Peter S Rabinovitch |
| MGI ID: |
MGI:3695678 |
| Synonyms: |
MCAT, Tg(CAT)4033Wcl |
| Transgene: |
Tg(CAG-OTC/CAT)4033Prab Location: unknown
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| Alliance: |
Tg(CAG-OTC/CAT)4033Prab page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(CAG-OTC/CAT)4033Prab expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
CAT (847) |
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Mutation details: To generate the transgene, the 11 carboxy-terminal amino acids, including the peroxisomal localization signal, were deleted from the human catalase gene. The initiating methionine was also deleted and the first 25 amino acids of the ornithine transcarbamylase leader sequence were added to the amino terminus to target this protein product to mitochondria. The catalase cDNA construct was then cloned into a plasmid under the influence of the chicken-actin promoter/CMV enhancer (CAG). The catalase activity in the cardiac mitochondrial fraction of transgenic animals is 50 times higher than that in their wild-type littermates.
(J:117831)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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| Original: |
J:117831 Schriner SE, et al., Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005 Jun 24;308(5730):1909-11 |
| All: |
43 reference(s) |
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Analysis Tools
