Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Camk2a-Crebbp*)1364Tabe
Name:	transgene insertion 1364, Ted Abel
MGI ID:	MGI:3712116
Synonyms:	CaMKIIalpha-CBPdelta1, CaMKIIalpha-FLAG-CBPdelta1, Tg(Camk2a-Crebbp)1364Tabe
Transgene:	Tg(Camk2a-Crebbp*)1364Tabe  Location: unknown
Alliance:	Tg(Camk2a-Crebbp*)1364Tabe page

Strain of Origin:

(C57BL/6 x SJL)F1

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Camk2a-Crebbp*)1364Tabe expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Crebbp (MGI:1098280)   Mutation details: A transgenic construct was designed with a FLAG-epitope sequence tag at the amino terminus of a truncated mouse CREB-binding protein sequence (called CBPdelta1; lacking the coding sequence for amino acids 1084-2441), all flanked by an artificial intron and splice sites at the 5' end and by a polyadenylation signal from SV40 at the 3' end. This FLAG-CBPD1 sequence was then placed downstream of 8.5 kb of the mouse CaMKIIalpha promoter. The resulting 13 kb "CaMKIIalpha-FLAG-CBPdelta1" transgene was microinjected into the pronuclei of B6SJLF1 zygotes. Expression of the truncated product is restricted to the post-natal hippocampus, striatum, amygdala, and cortex. (J:121812)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:121812 Wood MA, et al., Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage. Learn Mem. 2005 Mar-Apr;12(2):111-9
All:	1 reference(s)