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Gene Expression Data
Assay Details
Assay
Reference: J:47920 Dattani MT, et al., Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Nat Genet. 1998 Jun;19(2):125-33
Assay type: RNA in situ
MGI Accession ID: MGI:3711945
Gene symbol: Nkx2-1
Gene name: NK2 homeobox 1
Probe: Nkx2.1 probe13
Probe preparation: Antisense RNA
Results
Specimen 3l +/+: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: telencephalon floor plate Present 3l +/+

Specimen 3l -/-: embryonic day 9.5; Hesx1tm1Icar/Hesx1tm1Icar (more )
Structure Level Pattern Image Note
TS15: telencephalon floor plate Absent 3l -/- There is no expression in 50% of the mutants at this age.

Specimen Not shown: embryonic day 9.5; Hesx1tm1Icar/Hesx1tm1Icar (more )
Structure Level Pattern Image Note
TS15: telencephalon floor plate Present Expression is present in 50% of the mutants at this age.

Specimen Not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: diencephalon Present Regionally restricted Expression is present in the ventral diencephalon.
TS17: telencephalon Present Regionally restricted Expression is present in the medial ganglionic eminence.

Specimen Not shown: embryonic day 10.5; Hesx1tm1Icar/Hesx1tm1Icar (more )
Structure Level Pattern Image Note
TS17: diencephalon Present Regionally restricted As in wild-type, expression is present in the ventral diencephalon.
TS17: telencephalon Present Regionally restricted As in wild-type, expression is present in the medial ganglionic eminence.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory