Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(YAC353G6)W7Hay
Name:	transgene insertion W7, Michael Hayden
MGI ID:	MGI:3710982
Synonyms:	C6R7, YAC353G6
Transgene:	Tg(YAC353G6)W7Hay  Location: unknown
Alliance:	Tg(YAC353G6)W7Hay page

Strain of Origin:

FVB/NJ

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(YAC353G6)W7Hay expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human HTT (3064) Htt  (MGI:96067)   Mutation details: A YAC containing a full-length human huntingtin gene was modified with a 133 CAG repeat expansion in exon 1 and a mutation in exon 13, at position 586, which encodes the caspase-6 cleavage site. Founder line W7 (C6R7) was subsequently established. Caspase-6 cleavage products are not detected in brain lysates by Western blot. (J:120991)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:120991 Graham RK, et al., Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell. 2006 Jun 16;125(6):1179-91
All:	3 reference(s)