Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Epas1tm1.1Mcs
Name:	endothelial PAS domain protein 1; targeted mutation 1.1, M Celeste Simon
MGI ID:	MGI:3710344
Synonyms:	Hif-2adelta
Gene:	Epas1  Location: Chr17:87061292-87140838 bp, + strand  Genetic Position: Chr17, 56.9 cM
Alliance:	Epas1tm1.1Mcs page

Germline Transmission:	Earliest citation of germline transmission: J:119731
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 2 was deleted by a recombination event when 3LoxP founders were crossed to Tg(EIIa-cre)C5379 mice to remove the floxed Neo cassette during creation of the floxed (tm1Mcs) allele. (J:119731)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

List all tumor models in MMHCdb carrying Epas1tm1.1Mcs

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epas1 Mutation:	64 strains or lines available

Original:	J:119731 Gruber M, et al., Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2301-6
All:	4 reference(s)