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Tg(Camk2a-Bdnf)A9Stl
Transgene Detail
Summary
Symbol: Tg(Camk2a-Bdnf)A9Stl
Name: transgene insertion A9, Susumu Tonegawa
MGI ID: MGI:3709467
Transgene: Tg(Camk2a-Bdnf)A9Stl  Location: unknown  
Alliance: Tg(Camk2a-Bdnf)A9Stl page
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Camk2a-Bdnf)A9Stl expresses 1 gene
 
Mutation detailsThe transgene construct has the rat Bdnf cDNA sequence, with a Kozak sequence inserted in front of the translation initiation site, controlled by the mouse Camk2a promoter. The SV40 intron/polyA sequence was inserted the 3' to the Bdnf cDNA. ISH demonstrated that Bdnf overexpression is mainly restricted to the forebrain regions, including all of the neocortex, parts of the hippocampus, amygdala and striatum. (J:57645)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:57645 Huang ZJ, et al., BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell. 1999 Sep 17;98(6):739-55
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory