Summary | Transgene origin | Transgene description | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Ndor1Tg(UBC-cre/ERT2)1Ejb
Name:	NADPH dependent diflavin oxidoreductase 1; transgene insertion 1, Eric J Brown
MGI ID:	MGI:3707333
Synonyms:	Cre-ER, Cre-ERT2, CreT2, hUBC-CreERT2, Tg(UBC-cre)1Ejb, Tg(UBC-cre/ERT2)1Ejb, Tg(UBC-cre/ESR1)1Ejb, Ubc-cre, Ubc-creER, UBC-Cre-ER-LBD-tg, Ubc-cre/ERT2, UBC-CreERt2, UBC-CreERT2, UBC-CreERT2
Gene:	Ndor1  Location: Chr2:25134825-25145458 bp, - strand  Genetic Position: Chr2, 17.1 cM
Alliance:	Ndor1Tg(UBC-cre/ERT2)1Ejb page

Strain of Origin:

(129S/SvEv x C57BL/6)

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Ndor1Tg(UBC-cre/ERT2)1Ejb expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note human UBC (7316) Ubc  (MGI:98889)   Mutation details: This Cre-ERT2 transgenic mouse line was generated via lentitransgenesis; a self-inactivating lentiviral vector was designed with the human ubiquitin C (UBC) promoter sequence upstream of a Cre-ERT2 fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). Cre-ERT2-expressing lentivirus were microinjected into the perivitelline space of one-cell zygotes (129SvEv;C57BL/6 mixed genetic background). Mice display tamoxifen-inducible Cre activity in all tissue types. Line 1 inserted into the gene at 25249816-25249821 (Build GRCm38/mm10) resulting in a 5 bp deletion. (J:123200)

Activity:	Tissue activity of this recombinase allele
Driver:	UBC (human) Summary of all recombinase alleles driven by UBC. Comparative matrix view of recombinase activities Alliance human UBC gene page

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Ndor1Tg(UBC-cre/ERT2)1Ejb

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Ndor1 Mutation:	32 strains or lines available

Original:	J:123200 Ruzankina Y, et al., Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell. 2007 Jun 7;1(1):113-26
All:	484 reference(s)