Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe
Transgene Detail
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| Symbol: |
Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe |
| Name: |
transgene insertion 1, Corinne G Lobe |
| MGI ID: |
MGI:3703057 |
| Synonyms: |
IC-Notch1, Notch1-GFP, Tg(ACTB-Bgeo,-NOTCH1,-EGFP)1Lbe, Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe, Z/EG-Notch |
| Transgene: |
Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe Location: unknown
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| Alliance: |
Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe page
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| Transgene Type: |
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Transgenic (Conditional ready, Inserted expressed sequence, Reporter) |
| Mutation: |
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Insertion
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Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
NOTCH1 (4851) |
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Mutation details: A transgenic construct was designed with the CMV enhancer/chicken beta-actin promoter, loxP-flanked STOP sequence (beta-geo reporter followed by SV40 polyadenylation signal), Myc-tagged intracellular portion of human NOTCH1 (IC-Notch), internal ribosomal entry site, and an enhanced green fluorescent protein (EGFP) gene. Prior to cre-mediated excision of the "floxed" STOP sequence, high expression of lacZ is observed in cells and tissues. When bred to Cre recombinase expressing mice, the STOP sequence (and beta-geo) is removed in the resulting offspring, allowing transcription/co-expression of both the intracellular human NOTCH1 (IC-Notch) and EGFP to proceed in the Cre recombinase expressing cells and enabling tissue-specific studies of NOTCH expression using appropriate Cre mice.
(J:83045, J:119129)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:119129 Liu J, et al., Constitutive notch signaling in adult transgenic mice inhibits bFGF-induced angiogenesis and blocks ovarian follicle development. MGI Direct Data Submission. 2007; |
| All: |
13 reference(s) |
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Analysis Tools
