Tg(Igh-6-cre/ERT)30Afst
Transgene Detail
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| Symbol: |
Tg(Igh-6-cre/ERT)30Afst |
| Name: |
transgene insertion 30, A Francis Stewart |
| MGI ID: |
MGI:3702034 |
| Synonyms: |
Cre-EBD(G521R), CreED-30, Tg(Igh-6-cre/ESR1)30Afst |
| Transgene: |
Tg(Igh-6-cre/ERT)30Afst Location: unknown
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| Alliance: |
Tg(Igh-6-cre/ERT)30Afst page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Igh-6-cre/ERT)30Afst expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Igh |
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Mutation details: The transgene was created by combining the Igh-6 enhancer with a minimal SV40 promoter to drive the expression of a cre-ERT mutant fusion protein. The fusion protein consisted of cre recombinase fused to the estrogen binding domain of the human estrogen receptor mutated at amino acid 521 (G521R). Expression in ~ 75% of peripheral blood B lymphocytes was confirmed with an anti-cre antibody.
(J:69333)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Igh
(species not specified)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Line 30 is a representative expressing line; line 24 was also created with a similar expression pattern.
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| Original: |
J:69333 Schwenk F, et al., Temporally and spatially regulated somatic mutagenesis in mice. Nucleic Acids Res. 1998 Mar 15;26(6):1427-32 |
| All: |
6 reference(s) |
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Analysis Tools
