Tg(Tcrb3A)1Skd
Transgene Detail
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| Symbol: |
Tg(Tcrb3A)1Skd |
| Name: |
transgene insertion 1, Syamal Datta |
| MGI ID: |
MGI:3701765 |
| Synonyms: |
3A TCR beta-chain, Tg(Tcrb-V4)1Skd |
| Transgene: |
Tg(Tcrb3A)1Skd Location: unknown
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| Alliance: |
Tg(Tcrb3A)1Skd page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Tcrb3A)1Skd expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Tcrb (MGI:98578) |
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Mutation details: A rearranged mouse TCR Vbeta4-Dbeta-Jbeta2.6 genomic clone was derived from a T helper cell clone (3A) specific for nucleosomes and its immunodominant histone peptide H4 (71- 94). Eighty to ninety percent of CD4 T cells express the transgenic TCR.
(J:119333, J:119334, J:119335)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:119333 Michaels MA, et al., A defect in deletion of nucleosome-specific autoimmune T cells in lupus-prone thymus: role of thymic dendritic cells. J Immunol. 2005 Nov 1;175(9):5857-65 |
| All: |
3 reference(s) |
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Analysis Tools
