Tg(TcraY1,TcrbY1)416Tev Transgene Detail MGI Mouse (MGI:3700739)

Tg(TcraY1,TcrbY1)416Tev
Transgene Detail

Summary

Symbol:	Tg(TcraY1,TcrbY1)416Tev
Name:	transgene insertion 416, Satvir S Tevethia
MGI ID:	MGI:3700739
Synonyms:	line 416 TCR-I, Tag-I, TCR-I
Transgene:	Tg(TcraY1,TcrbY1)416Tev Location: unknown
Alliance:	Tg(TcraY1,TcrbY1)416Tev page

Transgene
origin

Strain of Origin:

(C57BL/6J x DBA/2J)F1/J

Transgene
description

Transgene Type:

Transgenic (Inserted expressed sequence)

Mutation:

Insertion

Tg(TcraY1,TcrbY1)416Tev expresses 2 genes

Mutation details: Single-cell embryos were coinjected with T-cell receptor alpha and T-cell receptor beta expression vectors containing the rearranged genomic Tcra and Tcrb VJ/V(D)J segments from the cytotoxic T-lymphocyte clone Y-1, which expresses a T cell receptor specific for the H2-D^b-restricted SV40 large tumor antigen epitope I (amino acids 206-215). (J:84288)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic mouse lines were derived from 2 transgene-expressing founder mice and designated lines 416 and 422. The Tg insert of line 416 was backcrossed onto C57BL/6 to create a congenic strain for use in experiments.

References

Original:	J:84288 Staveley-O'Carroll K, et al., In vivo ligation of CD40 enhances priming against the endogenous tumor antigen and promotes CD8+ T cell effector function in SV40 T antigen transgenic mice. J Immunol. 2003 Jul 15;171(2):697-707
All:	19 reference(s)

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