Tg(TERT)C10Hode Transgene Detail MGI Mouse (MGI:3700152)

Tg(TERT)C10Hode
Transgene Detail

Summary

Symbol:	Tg(TERT)C10Hode
Name:	transgene insertion C10, Richard J Hodes
MGI ID:	MGI:3700152
Synonyms:	BAC-C10, hTERT, hTERT-BAC-C10, line BAC-C10
Transgene:	Tg(TERT)C10Hode Location: unknown
Alliance:	Tg(TERT)C10Hode page

Transgene
origin

Strain of Origin:

C57BL/6

Transgene
description

Transgene Type:

Transgenic (Humanized sequence, Inserted expressed sequence)

Mutation:

Insertion

Tg(TERT)C10Hode expresses 1 gene

Mutation details: A linearized bacterial artificial chromosome (BAC) containing the 54-kb human telomerase reverse transcriptase gene, including at least 11 kb of upstream sequence, all of the exons and introns, and 1.2 kb of downstream sequence, was microinjected into C57BL/6 oocytes. Transcript expression patterns of the human gene in most organs of transgenic mice are generally characteristic of TERT expression in humans, rather than of the endogenous mouse gene; the exception is that human TERT, which is not expressed in human brain, is like the mouse enzyme expressed in mouse brain. (J:117922)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Mice of two independent transgenic founder lines, designated BAC-C2 and BAC-C10, were crossed with mice heterozygous for a targeted mutation of the endogenous mouse Tert gene to produce lines segregating for the transgene and the targeted mutation. Expression analyses were performed on mice of various genotypes from both lines. Most data presented were from line BAC-C10.

References

Original:	J:117922 Horikawa I, et al., Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18437-42
All:	2 reference(s)

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