Apba2tm1Sud
Targeted Allele Detail
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Symbol: |
Apba2tm1Sud |
Name: |
amyloid beta precursor protein binding family A member 2; targeted mutation 1, Thomas C Sudhof |
MGI ID: |
MGI:3697709 |
Gene: |
Apba2 Location: Chr7:64151454-64403626 bp, + strand Genetic Position: Chr7, 34.65 cM
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Alliance: |
Apba2tm1Sud page
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: The exon encoding amino acids 368-416 of the phosphotyrosine binding (PTB) domain is flanked by loxP sites. A single FRT site, the remnant of an FRT-flanked neomycin resistance cassette (neo) previously removed by crossing mice with the cassette to mice expressing Flp recombinase in the germline, is present in the downstream intron. (Retention of the neo cassette ablates expression of this gene in mice.) Immunoblot analysis of brain homogenates demonstrates that mice with this conditional mutation express the protein at wild-type levels.
(J:115573)
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Original: |
J:115573 Ho A, et al., Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. J Neurosci. 2006 Dec 13;26(50):13089-101 |
All: |
3 reference(s) |
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