Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Sfpi1,-EGFP)7Dgt
Name:	transgene insertion 7, Daniel G Tenen
MGI ID:	MGI:3696801
Synonyms:	URE-TG+
Transgene:	Tg(Sfpi1,-EGFP)7Dgt  Location: unknown
Alliance:	Tg(Sfpi1,-EGFP)7Dgt page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Sfpi1,-EGFP)7Dgt expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Spi1 (MGI:98282)   Mutation details: A Sfpi1 mini-gene comprising a 3.4-kb genomic DNA fragment containing the -14-kb upstream regulatory element (URE), a 2.1-kb genomic segment containing the promoter, and a cDNA representing the processed transcript of the gene is followed by an internal ribosome entry site (IRES), the enhanced green fluorescent protein (EGFP) coding sequence, and exon 2, intron 2, exon 3 and the polyadenylation signal of the rabbit beta-globin gene. Reporter expression is detected in a pattern similar to the endogenous gene, with high expression in myeloid cells, and to a lesser extent in B lymphocytes and erythroid cells. Expression is seen in total bone marrow, but is not detected in the thymus (J:117409)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:117409 Okuno Y, et al., Potential autoregulation of transcription factor PU.1 by an upstream regulatory element. Mol Cell Biol. 2005 Apr;25(7):2832-45
All:	4 reference(s)