Tg(CALCA-RET*C634R)1Bajp
Transgene Detail
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| Symbol: |
Tg(CALCA-RET*C634R)1Bajp |
| Name: |
transgene insertion 1, Bruce AJ Ponder |
| MGI ID: |
MGI:3525083 |
| Synonyms: |
2A-1, CT-2A-1 |
| Transgene: |
Tg(CALCA-RET*C634R)1Bajp Location: unknown
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| Alliance: |
Tg(CALCA-RET*C634R)1Bajp page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(CALCA-RET*C634R)1Bajp expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
RET (5979) |
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Transgene codes for a protein with a cysteine to arginine mutation. |
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Mutation details: A mutant human RET cDNA containing a cysteine to arginine mutation at codon 634 was flanked by the human calcitonin promoter and SV40 polyA sequences. Approximately ten copies of the transgene were incorporated into the genome. Transgene expression was strong in the pancreas and thyroid and weak in the lung. No expression was detected in the adrenal gland or kidney.
(J:70566)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:70566 Reynolds L, et al., C-cell and thyroid epithelial tumours and altered follicular development in transgenic mice expressing the long isoform of MEN 2A RET. Oncogene. 2001 Jul 5;20(30):3986-94 |
| All: |
1 reference(s) |
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Analysis Tools
