Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(CAG-OTC/CAT)4033Prab
Name:	transgene insertion 4033, Peter S Rabinovitch
MGI ID:	MGI:3695678
Synonyms:	MCAT, Tg(CAT)4033Wcl
Transgene:	Tg(CAG-OTC/CAT)4033Prab  Location: unknown
Alliance:	Tg(CAG-OTC/CAT)4033Prab page

Strain of Origin:

C57BL/6 x (C57BL/6 x C3H)F1

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(CAG-OTC/CAT)4033Prab expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human CAT (847) Cat  (MGI:88271)   Mutation details: To generate the transgene, the 11 carboxy-terminal amino acids, including the peroxisomal localization signal, were deleted from the human catalase gene. The initiating methionine was also deleted and the first 25 amino acids of the ornithine transcarbamylase leader sequence were added to the amino terminus to target this protein product to mitochondria. The catalase cDNA construct was then cloned into a plasmid under the influence of the chicken-actin promoter/CMV enhancer (CAG). The catalase activity in the cardiac mitochondrial fraction of transgenic animals is 50 times higher than that in their wild-type littermates. (J:117831)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:117831 Schriner SE, et al., Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005 Jun 24;308(5730):1909-11
All:	34 reference(s)