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Gene Expression Data
Assay Details
Assay
Reference: J:101193 Cromphout K, et al., Tissue distribution of the murine phosphomannomutases Pmm1 and Pmm2 during brain development. Eur J Neurosci. 2005 Aug;22(4):991-6
Assay type: Immunohistochemistry
MGI Accession ID: MGI:3694552
Gene symbol: Pmm2
Gene name: phosphomannomutase 2
Antibody: anti-Pmm2
Results
Specimen Not shown: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: brain ventricular layer Strong
TS21: cortical plate Strong Expression is present in the neurons of the preplate.
TS21: cerebellum Present Expression is present in the immature granule cells (both the granule cell progenitors and the migrating granule cells of the external granular layer).
TS21: cerebellum ventricular layer Moderate

Specimen Not shown: embryonic day 15.0 (more )
Structure Level Pattern Image Note
TS23: brain ventricular layer Strong
TS23: cortical plate Present
TS23: cerebral cortex intermediate zone Weak There is weak expression in the migrating neurons.

Specimen Not shown: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: brain ventricular layer Strong
TS25: cortical plate Present
TS25: cerebral cortex intermediate zone Weak There is weak expression in the migrating neurons.

Specimen 2B: postnatal day 0 (more )
Note: Higher magnification images shown in Fig. 2D & 2F.
Structure Level Pattern Image Note
TS27: brain Present 2B , 2D Expression is widespread. It is a cytoplasmic signal with a clear paranuclear localization. It is localized in the neuronal cell bodies. It is not pronounced in the cell extensions. Glia are mostly negative.
TS27: telencephalon Strong Non-Uniform 2B Expression is especially intense in the developing cerebrum, especially in the ventricular zone.
TS27: cerebral cortex Strong 2B , 2F There is intense expression in all cortical plate neurons.

Specimen 2H: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cortical layer II Present Uniform 2H Expression tends to be present in all neurons; no specific staining for a particular neuronal cell population was apparent.
TS28: cortical layer III Present Uniform 2H Expression tends to be present in all neurons; no specific staining for a particular neuronal cell population was apparent.
TS28: cortical layer IV Present Uniform 2H Expression tends to be present in all neurons; no specific staining for a particular neuronal cell population was apparent.
TS28: cortical layer V Present Uniform 2H Expression tends to be present in all neurons; no specific staining for a particular neuronal cell population was apparent.
TS28: cortical layer VI Present Uniform 2H Expression tends to be present in all neurons; no specific staining for a particular neuronal cell population was apparent.
TS28: cortical layer I Weak Non-Uniform 2H There is faint neuropil staining.
TS28: corpus callosum Absent 2H

Specimen 3B: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cerebellum external granule cell layer Present 3B
TS27: cerebellum internal granule cell layer Weak 3B

Specimen 3D: postnatal adult (more )
Note: Higher magnification images shown in Fig. 3F.
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Strong 3D , 3F There is intense staining in the cell body cytoplasm.
TS28: cerebellum granule cell layer Present 3D
TS28: cerebellum molecular layer Trace 3D There is faint neuropil staining.

Specimen 3J: postnatal adult (more )
Note: Higher magnification images shown in Fig. 3L.
Structure Level Pattern Image Note
TS28: hippocampus CA1 Present Regionally restricted 3J Expression is present in the pyramidal cells and some scattered polymorphic neurons.
TS28: hippocampus CA2 Present Regionally restricted 3J Expression is present in the pyramidal cells and some scattered polymorphic neurons.
TS28: hippocampus CA3 Present Regionally restricted 3J Expression is present in the pyramidal cells and some scattered polymorphic neurons.
TS28: hippocampus CA4 Moderate Single cells 3J Expression is present in scattered polymorphic neurons.
TS28: dentate gyrus Present Scattered 3L , 3J Expression is present in scattered polymorphic neurons.
TS28: dentate gyrus granule cell layer Present 3J , 3L
TS28: fimbria hippocampus Absent 3J


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory