Tg(Mt1-PML/RARA)135Adej
Transgene Detail
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| Symbol: |
Tg(Mt1-PML/RARA)135Adej |
| Name: |
transgene insertion 135, Anne Dejean |
| MGI ID: |
MGI:3529772 |
| Synonyms: |
MT-135, MT-PML-RARalpha |
| Transgene: |
Tg(Mt1-PML/RARA)135Adej Location: unknown
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| Alliance: |
Tg(Mt1-PML/RARA)135Adej page
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| Strain of Origin: |
(C57BL/6 x SJL/J)F2
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Mt1-PML/RARA)135Adej expresses
2 genes
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
PML (5371) |
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| human |
RARA (5914) |
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Mutation details: A 250 bp fragment of the mouse metallothionein promoter spanning nucleotides -185 to +65 was cloned upstream of a 4.6 kb fragment of the PML/RARA type L cDNA. The PML/RARA fusion gene included the RARA 3' untranslated region and the two presumed polyadenylation signals. 6 copies of the transgene were incorporated into the genome at a single site. ZnSo4 in the drinking water caused strong transgene induction in the liver after only 2 days of treatment (both at the mRNA and protein levels). Expression levels decreased with continuous treatment, with all expression lost by 30 days of treatment.
(J:87302)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:87302 David G, et al., The acute promyelocytic leukemia PML-RAR alpha protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice. Oncogene. 1997 Apr 3;14(13):1547-54 |
| All: |
1 reference(s) |
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Analysis Tools
