Tg(HBVX)1Gja
Transgene Detail
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| Symbol: |
Tg(HBVX)1Gja |
| Name: |
transgene insertion 1, Gilbert Jay |
| MGI ID: |
MGI:3512677 |
| Synonyms: |
E1, HBx E1 |
| Transgene: |
Tg(HBVX)1Gja Location: unknown
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| Alliance: |
Tg(HBVX)1Gja page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: A 1.15 kb fragment of HBV subtype adr DNA spanning nucleotides 707-1856 of the viral genome was cloned into CD-1 fertilized eggs. This DNA fragment contained the entire coding region of the HBx gene, transcriptional enshancer sequence, principal RNA start sites and a poly A site. Northern blot analysis confirmed transgene expression in the liver, kidney and testis. This allele was established in founder E1.
In J:90881, this allele was further defined to carry only a single copy of the transgene, and that the restriction sites bordering the transgene had been destroyed. Incidence of hepatocellular neoplasia in heterozygote transgenic mice was similar to CD-1 background, while incidence in homozygous transgenic mice carrying 2 copies of the transgene was elevated.
(J:78178)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:78178 Kim CM, et al., HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature. 1991 May 23;351(6324):317-20 |
| All: |
2 reference(s) |
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Analysis Tools
