Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ccnitm1Jro
Name:	cyclin I; targeted mutation 1, James M Roberts
MGI ID:	MGI:3693371
Synonyms:	I-
Gene:	Ccni  Location: Chr5:93329792-93354354 bp, - strand  Genetic Position: Chr5, 47.29 cM, cytoband E3.3-F1.3
Alliance:	Ccnitm1Jro page

Germline Transmission:	Earliest citation of germline transmission: J:115356
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The region of the gene encompassing all the coding exons except a small portion of the last exon was replaced by bacterial neomycin resistance and lacZ genes. No protein product from the targeted gene is detected by immunoblot analysis in tissue extracts of homozygous mutant 14- or 18-days post coitum (dpc) embryos or in mouse embryonic fibroblasts (MEFs) cultured from homozygous 13 dpc embryos. The highest levels of beta-galactosidase expression are detected by immunohistochemical analysis in brain, followed by testis, of one-month-old pups. In the kidney, distinct staining for beta-galactosidase is seen in a podocyte distribution in the glomerulus, and weaker, variable beta-galactosidase expression is seen in cells of the tubules. (J:115356)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccni Mutation:	24 strains or lines available

Original:	J:115356 Griffin SV, et al., Cyclin I protects podocytes from apoptosis. J Biol Chem. 2006 Sep 22;281(38):28048-57
All:	2 reference(s)